For the cheapest flights to Brussels book 45 days before departure.
The most popular airlines on the route Madrid - Brussels: Ryanair (FR), Iberia (IB), Air Europa (UX).
The cheapest flights are on the route Barajas (MAD) - Charleroi (CRL).
Direct flights last about 2h 15min.
Direct flights are available 7 days a week.
Direct flights: Iberia (IB), Ryanair (FR), Air Europa (UX).