For the cheapest flights to Rome book 36 days before departure.
The most popular airlines on the route Prague - Rome: Ryanair (FR), Wizz Air (W6), Czech Airlines (OK).
The cheapest flights are on the route Ruzyne (PRG) - Ciampino (CIA).
Direct flights last about 1h 44min.
Direct flights are available 7 days a week.
Direct flights: Ryanair (FR), Czech Airlines (OK), Alitalia (AZ).