For the cheapest flights to Madrid book 7 days before departure.
The most popular airlines on the route Pisa - Madrid: Ryanair (FR), British Airways (BA), Lufthansa (LH).
The cheapest flights are on the route Galileo Galilei (PSA) - Barajas (MAD).
Direct flights last about 2h 25min.
Direct flights available 6 days a week - Monday, Wednesday, Thursday, Friday, Saturday, Sunday.
Direct flights: Ryanair (FR).