We do not have enough data on this route to provide a reliable graph showing how many days before departure it is the best to book.
However, usually the closer it is to the departure, the more expensive the tickets are.
The most popular airlines on the route Pisa - Prague: Czech Airlines (OK), Germanwings (4U), Alitalia (AZ).
The cheapest flights you can book on the route Galileo Galilei (PSA) - Ruzyne (PRG).
Direct flights last about 2h 20min.
Direct flights available 2 days a week - Tuesday, Thursday.
Direct flights: Czech Airlines (OK).