For the cheapest flights to Santander book 6 days before departure.
The most popular airlines on the route Rome - Santander: Ryanair (FR), Iberia (IB).
The cheapest flights are on the route Ciampino (CIA) - Parayas (SDR).
Direct flights last about 2h 30min.
Direct flights available 4 days a week - Monday, Wednesday, Friday, Sunday.
Direct flights: Ryanair (FR).