Your travel platformSkip navigation

Scan the QR code and download our app

Tanie loty

Mexico City Panama - Cheap flights

Special flight deals from Mexico City to Panama

Why book flights with eSky?

Largest choice of flights

With flights from over 500 airlines, we'll find your perfect match in seconds.

Flexible search

Extend your search to include nearby airports and flex your dates for the cheapest deals.

Excellent products and services

Need travel insurance, cancellation insurance, car hire, local attraction bookings or more? We have you covered.

Over 4950 customer reviews - choose proven quality and book with complete confidence.

Find the best time to book cheap flights to Panama City

Flexible on travel dates? Discover the cheapest month to fly to Panama City

  • Cheapest round-trip flight

    from 318 USD
  • Cheapest month to travel

    December
  • The cheapest day to fly

    Thursday
  • Lowest prices

    1 day before
Aug
343 USD
Sep
343 USD
Oct
342 USD
Nov
343 USD
Dec
318 USD
Jan
383 USD
Feb
670 USD
Mar
670 USD
Apr
494 USD
May
669 USD
Jun
445 USD
Jul
669 USD

When is the best time to buy flight tickets?

Find out how far in advance it's worth booking round-trip flights.
  • 6 months before

    from

    500 USD

  • 3 months before

    from

    506 USD

  • 30 days before

    from

    594 USD

  • 7 days before

    from

    841 USD

  • 1 day before

    from

    375 USD

Discover the cheapest day to fly

Discover on which day of the week flights are usually the most affordable.
876 USD
Mon
507 USD
Tue
517 USD
Wed
487 USD
Thu
744 USD
Fri
683 USD
Sat
689 USD
Sun

General information

  • Local time (UTC-5) in Panama City

  • Flight time from Mexico City

  • Exchange Rate

    1 PAB = 1.00 USD
Panama
Panama is a country in Central America, situated on the Isthmus of Panama that connects North and South America. It shares borders with Costa Rica and Colombia. The capital, Panama City, is the nation’s largest urban center. Spanish is the official language. A major highlight is the Panama Canal, which significantly shortens the maritime route between the oceans. The country enjoys a tropical climate, with temperatures ranging from 24 to 29 °C. The best time to visit is during the dry season, from December to April. Panama’s economy is primarily based on services.