For the cheapest flights to Brussels book 26 days before departure.
The most popular airlines on the route Rome - Brussels: Ryanair (FR), Alitalia (AZ), Germanwings (4U).
The cheapest flights are on the route Ciampino (CIA) - Charleroi (CRL).
Direct flights last about 2h 5min.
Direct flights are available 7 days a week.
Direct flights: Ryanair (FR), Alitalia (AZ), Brussels Airlines (SN).